Photoaffinity labelling-based chemoproteomic strategy identifies PEBP1 as the target of ethyl gallate against macrophage activation

Author:

Yu Wei1,Liao Min2,Chen Yang1,Xue Rui1,Shi Xiao-Meng2,Liu Dan2,Zhuo Fang-Fang2,Tang Hui1,Lu Zhi-Yuan3ORCID,Tu Peng-Fei2,Han Bo1ORCID,Jia Xin1ORCID,Zeng Ke-Wu12ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering/School of Pharmacy/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Shihezi University, Shihezi 832003, China

2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

3. Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China

Abstract

Ulcerative colitis (UC) is an inflammatory disease of the colon with an unmet need for therapeutic targets.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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