Human spermbots for patient-representative 3D ovarian cancer cell treatment

Author:

Xu Haifeng12345ORCID,Medina-Sánchez Mariana1234ORCID,Zhang Wunan1234,Seaton Melanie P. H.678910ORCID,Brison Daniel R.11128910,Edmondson Richard J.1378910,Taylor Stephen S.678910,Nelson Louisa678910,Zeng Kang14151617,Bagley Steven14151617,Ribeiro Carla181920,Restrepo Lina P.181920,Lucena Elkin181920,Schmidt Christine K.678910,Schmidt Oliver G.12345

Affiliation:

1. Institute for Integrative Nanosciences

2. Leibniz IFW Dresden

3. 01069 Dresden

4. Germany

5. Research Centre for Materials

6. Manchester Cancer Research Centre

7. Division of Cancer Sciences

8. School of Medical Sciences

9. Faculty of Biology

10. Medicine and Health

11. Maternal and Fetal Health Research Centre

12. Division of Developmental Biology and Medicine

13. Gynaecological Oncology

14. Advanced Imaging and Flow Cytometry

15. Cancer Research UK Manchester Institute

16. University of Manchester

17. UK

18. Colombian Center of Fertiliy and Sterility (CECOLFES)

19. Bogotá

20. Colombia

Abstract

Human-sperm driven micromotors are attractive for locally delivering high concentrations of drug in hard-to-reach disease sites such as cervical cancer and early ovarian cancer lesions by non-invasive means.

Funder

China Scholarship Council

Biotechnology and Biological Sciences Research Council

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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