Inhibition of voltage-gated K+ channels mediates docosahexaenoic acid-stimulated insulin secretion in rat pancreatic β-cells

Author:

Bai Tao12345ORCID,Yang Huanhuan1234ORCID,Wang Hui1234ORCID,Zhi Linping1234ORCID,Liu Tao12345ORCID,Cui Lijuan12345ORCID,Liu Wen6234ORCID,Wang Yan1234ORCID,Zhang Min7234ORCID,Liu Yunfeng89234ORCID,Zhang Yi12345ORCID

Affiliation:

1. Department of Pharmacology

2. Shanxi Medical University

3. Taiyuan

4. P. R. China

5. Key Laboratory of Cellular Physiology

6. Department of Chemistry

7. Department of Pharmacy

8. Department of Endocrinology

9. the First Hospital of Shanxi Medical University

Abstract

Kv channels play a vital role in DHA-augmented insulin secretion through GPR40/AC/cAMP/PLC signaling pathway in rat pancreatic β-cells.

Funder

National Natural Science Foundation of China

Shanxi Scholarship Council of China

Department of Education, Shanxi Province

Natural Science Foundation of Shanxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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