The extensive solid-form landscape of sulfathiazole: geometrical similarity and interaction energies

Author:

Hughes David S.12ORCID,Bingham Ann L.2,Hursthouse Michael B.2,Threlfall Terry L.2,Bond Andrew D.1ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

2. School of Chemistry, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, SO17 1BJ, UK

Abstract

Sulfathiazole shows one of the most extensive solid-form landscapes known to date for an active pharmaceutical ingredient. A standardised structure set of 5 polymorphs, 59 co-crystals, 29 salts, and 3 other structures is established.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Reference51 articles.

1. Computational Pharmaceutical Solid State Chemistry , ed. Y. A. Abramov , Wiley , Hoboken, New Jersey , 2016

2. J.Bernstein , Polymorphism in Molecular Crystals , Oxford University Press , Oxford , 2nd edn, 2020

3. A. D.Bond , Pharmaceutical Crystallography: A Guide to Structure and Analysis , Royal Society of Chemistry , Cambridge , 2019

4. Polymorphism and Solvatomorphism 2010

5. S. R.Byrn , R. R.Pfeiffer and J. G.Stowell , Solid-State Chemistry of Drugs , SSCI, Inc. , West Lafayette, Indiana, USA , 2nd edn, 1999

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