Natural products modulating the hERG channel: heartaches and hope-Reference-Cited by-同舟云学术

Natural products modulating the hERG channel: heartaches and hope

Published:2017 Issue:8 Volume:34 Page:957-980
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Kratz Jadel M.¹²³⁴⁵^ORCID,Grienke Ulrike¹²³⁴⁵^ORCID,Scheel Olaf⁶⁷⁸,Mann Stefan A.⁶⁷⁸,Rollinger Judith M.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacognosy

2. Faculty of Life Sciences

3. University of Vienna

4. 1090 Vienna

5. Austria

6. CytoBioScience GmbH

7. 50829 Cologne

8. Germany

Abstract

This review covers natural products modulating the hERG potassium channel. Risk assessment strategies, structural features of blockers, and the duality target/antitarget are discussed.

Funder

Seventh Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NP/C7NP00014F

Reference164 articles.

1. The hERG K+ channel: target and antitarget strategies in drug development

2. hERG potassium channels and cardiac arrhythmia

3. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

4. Predicting drug–hERG channel interactions that cause acquired long QT syndrome

5. hERG K+Channels: Structure, Function, and Clinical Significance

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