Doxorubicin delivery performance of superparamagnetic carbon multi-core shell nanoparticles: pH dependence, stability and kinetic insight-Reference-Cited by-同舟云学术

Doxorubicin delivery performance of superparamagnetic carbon multi-core shell nanoparticles: pH dependence, stability and kinetic insight

Published:2022 Issue:19 Volume:14 Page:7220-7232
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Silva Adriano Santos¹^ORCID,Diaz de Tuesta Jose Luis²^ORCID,Sayuri Berberich Thais¹²,Delezuk Inglez Simone²,Bertão Ana Raquel³,Çaha Ihsan³^ORCID,Deepak Francis Leonard³^ORCID,Bañobre-López Manuel³^ORCID,Gomes Helder Teixeira¹

Affiliation:

1. Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus Santa Apolónia, 5300-253, Bragança, Portugal

2. Universidade Tecnológica Federal do Paraná, Campus Ponta Grossa, 84017-220, Ponta Grossa, Paraná, Brazil

3. Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre Jose Veiga s/n, 4715-330 Braga, Portugal

Abstract

Multi-core shell nanoparticles reach a doxorubicin (DOX) loading capacity of 936 μg mg−1 and DOX release values of 8.3 to 76% from pH 7.4 to 4.5. Kinetic models were able to predict pH-dependent path drug release.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR08550F

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