Synthesis andin vivoevaluation of a radiofluorinated ketone body derivative-Reference-Cited by-同舟云学术

Synthesis andin vivoevaluation of a radiofluorinated ketone body derivative

Published:2020 Issue:2 Volume:11 Page:297-306
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Mattingly Stephanie J.¹²³⁴^ORCID,Wuest Melinda¹²³⁴⁵,Fine Eugene J.⁶⁷⁸⁹,Schirrmacher Ralf¹²³⁴¹⁰^ORCID,Wuest Frank¹²³⁴⁵^ORCID

Affiliation:

1. Department of Oncology

2. University of Alberta

3. Edmonton

4. Canada

5. Cancer Research Institute of Northern Alberta

6. Department of Radiology (Nuclear Medicine)

7. Albert Einstein College of Medicine/Montefiore Medical Center

8. NY

9. USA

10. Department of Chemistry

Abstract

Design, synthesis, and preliminary validation of the first radiofluorinated ketone body derivative as a PET imaging agent for the study of ketone body metabolism in cancer.

Funder

Natural Sciences and Engineering Research Council of Canada

Alberta Cancer Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00486F

Reference50 articles.

1. Using positron emission tomography to study human ketone body metabolism: A review

2. Ketone bodies as signaling metabolites

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