Development of potent CPP6–gemcitabine conjugates against human prostate cancer cell line (PC-3)-Reference-Cited by-同舟云学术

Development of potent CPP6–gemcitabine conjugates against human prostate cancer cell line (PC-3)

Published:2020 Issue:2 Volume:11 Page:268-273
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Correia Cristiana¹²³⁴⁵,Xavier Cristina P. R.⁶⁷⁸⁹¹⁰^ORCID,Duarte Diana¹²³⁴⁵^ORCID,Ferreira Abigail¹²³⁴⁵^ORCID,Moreira Sara¹²³⁴⁵,Vasconcelos M. Helena⁶⁷⁸⁹¹⁰^ORCID,Vale Nuno¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Pharmacology

2. Department of Drug Sciences

3. Faculty of Pharmacy

4. University of Porto

5. 4050-313 Porto

6. Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)

7. Rua Júlio Amaral de Carvalho

8. 4200-135 Porto

9. Portugal

10. Instituto de Investigação e Inovação em Saúde (i3S)

Abstract

Gemcitabine conjugation with CPP6 significantly enhanced cell growth inhibitory activity on PC-3 cells, with IC₅₀ between 14 and 15 nM.

Funder

Fundação para a Ciência e a Tecnologia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00489K

Reference56 articles.

1. Gemcitabine versus Modified Gemcitabine: A Review of Several Promising Chemical Modifications

2. Inhibition of thymidylate synthase by 2′,2′-difluoro-2′-deoxycytidine (Gemcitabine) and its metabolite 2′,2′-difluoro-2′-deoxyuridine

3. DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine

4. Cellular pharmacology of gemcitabine

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