New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5
Author:
Affiliation:
1. Department of Chemistry
2. 11227 Saskatchewan Drive University of Alberta
3. Edmonton
4. Canada T6G 2G2
5. Department of Physiology
6. University of Alberta
7. Canada T6G 2H7
8. Department of Oncology
9. Cross Cancer Institute
10. Canada T6G 1Z2
Abstract
Two fluorinated fructose analogs are taken up by tumor cells in culture. Their high affinity for the transporter protein GLUT5 provides information on the structural demands of its binding site, and suggests approaches towards new molecular imaging probes.
Funder
Natural Sciences and Engineering Research Council of Canada
Canadian Breast Cancer Foundation
Canadian Institutes of Health Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00314H
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