Cabazitaxel-loaded redox-responsive nanocarrier based on d-alpha-tocopheryl-chitosan and hyaluronic acid for improved anti-tumor efficacy in DMBA-induced breast cancer model

Author:

Jha Abhishek1ORCID,Kumar Manish1ORCID,Goswami Pooja2ORCID,Bharti Kanchan1ORCID,Manjit Manjit1ORCID,Gupta Ashutosh3ORCID,Moorkoth Sudheer3ORCID,Koch Biplob2ORCID,Mishra Brahmeshwar1ORCID

Affiliation:

1. Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (BHU), Varanasi - 221005, Uttar Pradesh, India

2. Genotoxicology and Cancer Biology Laboratory, Department of Zoology Institute of Science, Banaras Hindu University, Varanasi - 221005, Uttar Pradesh, India

3. Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal - 576104, Karnataka, India

Abstract

The study involved the formulation and evaluation of cabazitaxel loaded d-alpha-tocopheryl succinate/chitosan conjugate (CSVE) and hyaluronic acid (HA) based redox-responsive nanoparticle crosslinked using 3,3′-dithiodipropionic acid (DTPA).

Funder

Banaras Hindu University

Publisher

Royal Society of Chemistry (RSC)

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