Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans

Author:

Velásquez-Hernández Miriam de J.1234ORCID,Astria Efwita1234ORCID,Winkler Sarah1234,Liang Weibin5678ORCID,Wiltsche Helmar92104,Poddar Arpita111213148ORCID,Shukla Ravi111213148ORCID,Prestwich Glenn15161718,Paderi John192018,Salcedo-Abraira Pablo21222324ORCID,Amenitsch Heinz252104ORCID,Horcajada Patricia21222324ORCID,Doonan Christian J.5678ORCID,Falcaro Paolo1234ORCID

Affiliation:

1. Institute of Physical and Theoretical Chemistry

2. Graz University of Technology

3. Graz 8010

4. Austria

5. School of Physical Sciences

6. Faculty of Sciences

7. University of Adelaide

8. Australia

9. Institute of Analytical Chemistry and Food Chemistry

10. 8010 Graz

11. School of Science

12. Nanobiotechnology Research Laboratory (NBRL)

13. RMIT University

14. 3001 Melbourne

15. The University of Utah

16. College of Pharmacy

17. Salt Lake City

18. USA

19. Symic. Bio, Inc.

20. San Francisco

21. Advanced Porous Materials Unit (APMU)

22. IMDEA Energy

23. E-28935 Móstoles

24. Spain

25. Institute of Inorganic Chemistry

Abstract

Clinical and pre-clinical GAG-based biotherapeutics were encapsulated within three metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The resulting MOF biocomposites show different loading capacity, biopreservation properties and release profiles.

Funder

Horizon 2020

Consejo Nacional de Ciencia y Tecnología

Österreichische Agentur für Internationale Mobilität und Kooperation in Bildung, Wissenschaft und Forschung

Australian Research Council

Australian Nanotechnology Network

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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