Catalyst-free [3 + 2] cyclization of dihydroisoquinoline imines and isatin-derived Morita–Baylis–Hillman carbonates via 1,5-electrocyclization: synthesis of tetrahydroisoquinoline-fused spirooxindoles-Reference-Cited by-同舟云学术

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Catalyst-free [3 + 2] cyclization of dihydroisoquinoline imines and isatin-derived Morita–Baylis–Hillman carbonates via 1,5-electrocyclization: synthesis of tetrahydroisoquinoline-fused spirooxindoles

Published:2018 Issue:18 Volume:16 Page:3362-3366
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tang Xue¹²³⁴⁵,Gao Ying-Juan⁶⁷⁸⁹,Deng Hui-Qing⁶⁷⁸⁹,Lei Jin-Ju⁶⁷⁸⁹,Liu Si-Wei⁶⁷⁸⁹,Zhou Lin⁶⁷⁸⁹,Shi Yin⁶⁷⁸⁹,Liang Hao⁶⁷⁸⁹,Qiao Jie⁶⁷⁸⁹,Guo Li¹²³⁴⁵,Han Bo¹²³⁴⁵^ORCID,Cui Hai-Lei⁶⁷⁸⁹^ORCID

Affiliation:

1. State Key Laboratory Breeding Base of Systematic Research

2. Development and Utilization of Chinese Medicine Resources

3. School of Pharmacy

4. Chengdu University of Traditional Chinese Medicine

5. Chengdu 611137

6. Laboratory of Asymmetric Synthesis

7. Chongqing University of Arts and Sciences

8. Yongchuan

9. P.R. China

Abstract

The incorporation of tetrahydroisoquinoline and spirooxindole frameworks has been achieved.

Funder

National Natural Science Foundation of China

Chongqing University of Arts and Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00749G

Reference78 articles.

1. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

2. Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

3. Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

4. Concise Total Synthesis of (±)-Marcfortine B

5. Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

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2. Diastereoselective Three-Component 1,3-Dipolar Cycloaddition to Access Functionalized β-Tetrahydrocarboline- and Tetrahydroisoquinoline-Fused Spirooxindoles;Molecules;2024-04-15

3. Molecular Diversity of Base Promoted Annulation of MBH Carbonates of Isatins and Dialkyl But‐2‐ynedioates;ChemistrySelect;2023-10-19

4. Substrate-Controlled Diversity-Oriented Synthesis of Novel Polycyclic Frameworks via [4 + 2] and [3 + 2] Annulations of Ninhydrin-Derived MBH Adducts with 3,4-Dihydroisoquinolines;Molecules;2023-09-22

5. Spirooxindoles: Recent report of green synthesis approach;Green Synthesis and Catalysis;2023-08

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