1. Handbook of Grignard Reagents, ed. G. S. Silverman and P. E. Rakita, Marcel Dekker, New York, 1996
2. The quest for chiral Grignard reagents
3. New Insights into the Classic Chiral Grignard Reagent (1R,2S,5R)-Menthylmagnesium Chloride
4. Nuclear Magnetic Resonance Spectra of the Bornyl and Norbornyl Grignard Reagents1
5. Synthesis of the bornyl and fenchyl Grignard reagent. A solution of isobornyl chloride or β-fenchyl chloride (17.2 g, 100 mmol) in THF (180 mL) was slowly added to a suspension of activated Mg turnings (2.7 g, 110 mmol) in THF (20 mL). After the addition was completed, the mixture was heated under reflux for 12 h. Prior to use, the clear solution was separated from the excess of Mg via cannula. The yield determined by titration was about 80%. Synthesis of the epimerized bornyl and fenchyl Grignard reagent. A solution of the bornyl or fenchyl Grignard reagent was slowly distilled while toluene (220 mL) was constantly added to replace the original solvent THF. The temperature was slowly raised to 111 °C and kept there for 12 h. The yield determined by titration was between 65 and 75%