Substrate viscoelasticity affects human macrophage morphology and phagocytosis-Reference-Cited by-同舟云学术

Substrate viscoelasticity affects human macrophage morphology and phagocytosis

Published:2023 Issue:13 Volume:19 Page:2438-2445
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Kalashnikov Nikita¹^ORCID,Moraes Christopher¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering, McGill University, Montreal, Canada

2. Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada

3. Goodman Cancer Research Center, McGill University, Montreal, Canada

4. Division of Experimental Medicine, McGill University, Montreal, Canada

Abstract

Using viscoelastically-tunable polyacrylamide hydrogels, we show that macrophage morphology and phagocytosis depend on substrate loss modulus, indicating that viscoelasticity may be an important design parameter in immunomodulatory biomaterials.

Funder

Natural Sciences and Engineering Research Council of Canada

Fonds de Recherche du Québec - Nature et Technologies

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SM/D2SM01683D

Reference46 articles.

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