Efficient total synthesis of neocryptolepine and synthetic access to 6-methylquinindoline from a common intermediate

Author:

Méndez María V.123ORCID,Heredia Daniel A.123ORCID,Larghi Enrique L.123ORCID,Bracca Andrea B. J.123ORCID,Kaufman Teodoro S.123ORCID

Affiliation:

1. Instituto de Química Rosario (CONICET-UNR)

2. Rosario

3. Argentina

Abstract

The total synthesis of neocryptolepine and the synthesis of its non-natural isomer 6-methyl quinindoline were efficiently achieved in a few steps from a common intermediate.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference114 articles.

1. A. A. Appiah , The Golden Roots of Cryptolepis sanguinolenta, in Chemistry and Quality - African Natural Plant Products: New Discoveries and Challenges, ACS, Washington, D.C., 2009, ch. 13, pp. 231–239

2. F. R. Irvine , in Woody Plants of Ghana, Oxford University Press, London, 1961

3. P. T. Parvatkar and S. G.Tilve, Bioactivities and synthesis of indoloquinoline alkaloids: cryptolepine, isocryptolepine and neocryptolepine, in Bioactive Heterocycles: Synthesis and Biological Evaluation, ed. K. L. Ameta, R. P. Pawar and A. J. Domb, Nova Science Publishers, 2012, ch. 10, pp. 218–233

4. Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

5. Indoloquinolines as Scaffolds for Drug Discovery

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