Selenium substitution endows cystine with radiosensitization activity against cervical cancer cells
Author:
Affiliation:
1. Department of Chemistry
2. Jinan University
3. Guangzhou 510632, China
4. Wu Jing Zong Dui Hospital of Guangdong Province
5. Guangzhou, China
Abstract
Selenium substitution could endow cystine the radiosensitization activity against cervical cancer HeLa cells through overproduction of ROS and activation of downstream signaling, which suggests this could be a novel strategy for design of cancer radiosensitizers.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA07031C
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