Tuning of endosomal escape and gene expression by functional groups, molecular weight and transfection medium: a structure–activity relationship study
Author:
Affiliation:
1. Laboratory of Organic and Macromolecular Chemistry (IOMC)
2. Friedrich Schiller University Jena
3. 07743 Jena
4. Germany
5. Jena Center for Soft Matter (JCSM)
Abstract
A library of cationic polyacrylamide homopolymers was synthesized and their gene delivery, endosomal release, and interaction with endosome-specific lipids were investigated. The guanidinium-containing polymers were most efficient.
Funder
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering,General Chemistry,General Medicine
Link
http://pubs.rsc.org/en/content/articlepdf/2020/TB/D0TB00340A
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