A hydroxychloroquine platinum(<scp>iv</scp>) conjugate displaying potent antimetastatic activities by suppressing autophagy to improve the tumor microenvironment-Reference-Cited by-同舟云学术

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A hydroxychloroquine platinum(iv) conjugate displaying potent antimetastatic activities by suppressing autophagy to improve the tumor microenvironment

Published:2024 Issue:33 Volume:53 Page:13890-13905
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Li Linming¹,Chen Yan¹,Zhang Ming¹,Li Suying¹,Feng Shuaiqi¹,He Yan-Qin¹,Zhang Ning¹^ORCID,Liu Zhifang¹,Liu Meifeng²,Wang Qingpeng¹^ORCID

Affiliation:

1. Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China

2. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Abstract

A hydroxychloroquine platinum(iv) complex targeting autophagy was developed as an antitumor agent with promising antiproliferative and antimetastatic activities.

Funder

Youth Innovation Technology Project of Higher School in Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT01794C

Reference36 articles.

1. Metastasis

2. Hallmarks of Cancer: New Dimensions

3. Mechanisms of cancer metastasis

4. Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models

5. m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

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