Small organic molecule-based nanoparticles with red/near-infrared aggregation-induced emission for bioimaging and PDT/PTT synergistic therapy

Author:

Yang Mengqian12345,Deng Jingran12345,Su Huifang6785,Gu Shuangxi12345,Zhang Jie910115ORCID,Zhong Aiguo910115,Wu Fengshou12345ORCID

Affiliation:

1. Key Laboratory for Green Chemical Process of Ministry of Education

2. School of Chemical Engineering and Pharmacy

3. Wuhan Institute of Technology

4. Wuhan

5. P. R. China

6. Department of Orthopaedic Surgery

7. The First Affiliated Hospital of Zhengzhou University

8. Zhengzhou

9. Department of Chemistry

10. School of Pharmaceutical and Materials Engineering, Taizhou University

11. Taizhou

Abstract

An organic small molecule T-BDP with D–A–D structure was designed and synthesized and could self-assemble into nanoparticles with significant AIE performance. Under 635 nm laser irradiation, T-BDP NPs ablate cancer cells through photodynamic/photothermal synergistic effects.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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