Substitution of the methyl groups with ethyl groups at C-10 and C-15 of 2,3-oxidosqualene halts the enzymatic reaction of oxidosqualene–lanosterol cyclase at the monocyclic ring stage-Reference-Cited by-同舟云学术

Substitution of the methyl groups with ethyl groups at C-10 and C-15 of 2,3-oxidosqualene halts the enzymatic reaction of oxidosqualene–lanosterol cyclase at the monocyclic ring stage

Published:1995 Issue:23 Volume: Page:2401-2402
ISSN:0022-4936
Container-title:J. Chem. Soc., Chem. Commun.
language:en
Short-container-title:J. Chem. Soc., Chem. Commun.

Author:

Hoshino Tsutomu,Ishibashi Eiichi,Kaneko Kimiyoshi

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/1995/C3/C39950002401

Reference13 articles.

1. Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes

2. Enzymic cyclization of 15-norsqualene 2,3-oxide

3. The methyl group at C(10) of 2,3-oxidosqualene is crucial to the correct folding of this substrate in the cyclization-rearrangement step of sterol biosynthesis

4. Vinyl group rearrangement in the enzymic cyclization of squalenoids: synthesis of 30-oxysterols

5. Synthesis of 10,15-[13C2]-squalene and -DL-squalene oxide

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