An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

Author:

Grace James L.12345ORCID,Amado Maite6784ORCID,Reid Janet C.910114,Elliott Alysha G.6784ORCID,Landersdorfer Cornelia B.5121323ORCID,Truong Nghia P.12345ORCID,Kempe Kristian12345ORCID,Cooper Matthew A.6784ORCID,Davis Thomas P.12345ORCID,Montembault Véronique14151617ORCID,Pascual Sagrario14151617ORCID,Fontaine Laurent14151617ORCID,Velkov Tony1819202122ORCID,Quinn John F.12345ORCID,Whittaker Michael R.12345ORCID

Affiliation:

1. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

2. Monash University

3. Parkville

4. Australia

5. Drug Delivery

6. Institute of Molecular Biosciences

7. The University of Queensland

8. Brisbane

9. Australian Institute of Bioengineering and Nanotechnology

10. University of Queensland

11. St Lucia

12. Disposition and Dynamics Theme

13. Monash Institute of Pharmaceutical Sciences

14. Institut des Molécules et Matériaux du Mans

15. UMR 6283 CNRS – Le Mans Université

16. 72085 Le Mans Cedex 9

17. France

18. Department of Pharmacology & Therapeutics

19. School of Biomedical Sciences

20. Faculty of Medicine

21. Dentistry and Health Sciences

22. The University of Melbourne

Abstract

For the first time Cu(0)-RDRP conditions were optimised to allow for the fast and controlled polymerisation of vinyl azlactone with tuneable lipid elements: a versatile platform material for the high-throughput synthesis of antimicrobial materials.

Funder

Wellcome Trust

Australian Research Council

National Health and Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference66 articles.

1. W. H. Organization, Antimicrobial Resistance: Global Report on Surveillance, Organization WH, editor, World Health Organization, 2014

2. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

3. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

4. J. O'Neill . Antimicrobial Resistance: Tackling a crisis for the health and wealth of nations . The Review on Antimicrobial Resistance , 2014

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