Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6-Reference-Cited by-同舟云学术

Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6

Published:2023 Issue:44 Volume:14 Page:12484-12497
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ye Xiyun¹,Zhang Peiyuan¹^ORCID,Tao Jason¹,Wang John C. K.²^ORCID,Mafi Amirhossein²,Grob Nathalie M.¹,Quartararo Anthony J.¹,Baddock Hannah T.²,Chan Leanne J. G.²^ORCID,McAllister Fiona E.²^ORCID,Foe Ian²,Loas Andrei¹^ORCID,Eaton Dan L.²,Hao Qi²,Nile Aaron H.²,Pentelute Bradley L.¹³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

2. Calico Life Sciences LLC, 1170 Veterans Boulevard, South San Francisco, CA 94080, USA

3. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA

4. Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA

5. Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA

Abstract

A covalent peptide ligand mimicking the binding motif in the E6AP protein selectively crosslinks to HPV16 E6 with quantitative conversion. This ‘reactide’ provides a starting point in the development of inhibitors against HPV-driven cancers.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02782A

Reference88 articles.

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5. Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment

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