Navigating the challenges of lipid nanoparticle formulation: the role of unpegylated lipid surfactants in enhancing drug loading and stability-Reference-Cited by-同舟云学术

Navigating the challenges of lipid nanoparticle formulation: the role of unpegylated lipid surfactants in enhancing drug loading and stability

Published:2024 Issue:2 Volume:6 Page:669-679
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Hogarth Cameron¹,Arnold Keith²,Wright Steve¹,Elkateb Heba¹,Rannard Steve¹²^ORCID,McDonald Tom O.¹³⁴^ORCID

Affiliation:

1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK

2. Material Innovation Factory, University of Liverpool, Liverpool, L7 3NY, UK

3. Department of Materials, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK

4. Henry Royce Institute, The University of Manchester, Oxford Road, Manchester, UK

Abstract

The study emphasises non-pegylated helper lipids functioning as both surfactants and contributors to the lipid nanoparticle core, enhancing stability at higher core percentages and potentially disrupting core crystallinity in blended formulations.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NA/D3NA00484H

Reference34 articles.

1. Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice

2. Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

3. Theory, Production and Mechanism of Formation of Monodispersed Hydrosols

4. Principles of nanoparticle formation by flash nanoprecipitation

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