Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters-Reference-Cited by-同舟云学术

Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters

Published:2023 Issue:9 Volume:13 Page:5778-5795
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

El-Hawary Seham S.¹,Hassan Marwa H. A.²^ORCID,Hudhud Ahmed O.³,Abdelmohsen Usama Ramadan⁴⁵^ORCID,Mohammed Rabab²

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt

2. Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt

3. Department of Pharmacognosy, Faculty of Pharmacy, Merit University, Sohag 82511, Egypt

4. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

5. Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt

Abstract

Elicitation of secondary metabolites in actinomycetes: (TFD) Transcription Factor Decoys, (ORG) Overexpression of regulatory genes, (PRS) Promoter Replacement Strategy, (GRG) Global regulatory gene, (RGMS) Reporter-guided Mutant Selection.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D2RA08222E

Reference84 articles.

1. Diversity, abundance and natural products of marine sponge-associated actinomycetes

2. A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

3. Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics

4. Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene, adpA, in Streptomyces ansochromogenes

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