PROTACs: past, present and future-Reference-Cited by-同舟云学术

PROTACs: past, present and future

Published:2022 Issue:12 Volume:51 Page:5214-5236
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Li Ke¹,Crews Craig M.¹²³^ORCID

Affiliation:

1. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA

2. Department of Chemistry, Yale University, New Haven, Connecticut 06511, USA

3. Department of Pharmacology, Yale University, New Haven, Connecticut 06511, USA

Abstract

This review highlights important milestones in the evolution of PROTACs, briefly discusses recent lessons about targeted protein degradation, and conjectures on the efforts still needed to expand the toolbox for PROTAC discovery.

Funder

American Cancer Society

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00193D

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