Development of a highly efficient single-mode microwave applicator with a resonant cavity and its application to continuous flow syntheses

Author:

Yokozawa Saori123,Ohneda Noriyuki123,Muramatsu Ken123,Okamoto Tadashi123,Odajima Hiromichi123,Ikawa Takashi4563,Sugiyama Jun-ichi783,Fujita Masashi910113,Sawairi Taira910113,Egami Hiromichi910113,Hamashima Yoshitaka910113,Egi Masahiro910113,Akai Shuji4563

Affiliation:

1. SAIDA FDS INC.

2. Yaizu

3. Japan

4. Graduate School of Pharmaceutical Sciences

5. Osaka University

6. Suita

7. National Institute of Advanced Industrial Science and Technology

8. Tsukuba

9. School of Pharmaceutical Sciences

10. University of Shizuoka

11. Shizuoka

Abstract

A new microwave applicator specifically designed for continuous flow synthesis has been developed and tested in the Fischer indole synthesis and in the Diels–Alder reaction to afford the reaction products at a scale of 100 g h−1.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference49 articles.

1. Microwave-Assisted Chemistry: Synthetic Applications for Rapid Assembly of Nanomaterials and Organics

2. Role of microwaves in heterogeneous catalytic systems

3. A. de la Hoz and A.Loupy, Microwaves in Organic Synthesis, Wiley-VCH, Weinheim, 3rd edn, 2013

4. R. S. Varma , in Innovations in Green Chemistry and Green Engineering, ed. P. T. Anastas and J. B. Zimmerman, Springer, New York, 2013, ch. 5, pp. 115–156

5. RECENT ADVANCES OF QUINAZOLINONE DERIVATIVES AS MARKER FOR VARIOUS BIOLOGICAL ACTIVITIES

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