Total synthesis of fluoxetine and duloxetine through an in situ imine formation/borylation/transimination and reduction approach
Author:
Affiliation:
1. Centre for Sustainable Chemical Processes
2. Department of Chemistry
3. Durham University
4. Durham, UK
5. Departament Química Física I Inorgànica
6. University Rovira I Virgili
7. Tarragona, Spain
Abstract
Efficient, catalytic, asymmetric total syntheses of both (R)-fluoxetine and (S)-duloxetine from α,β-unsaturated aldehydes are reported.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01142B
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