Modulation of aggregation with an electric field; scientific roadmap for a potential non-invasive therapy against tauopathies

Author:

Pandey Gaurav1234,Morla Sudhir1234,Nemade Harshal B.5234,Kumar Sachin1234,Ramakrishnan Vibin1234ORCID

Affiliation:

1. Department of Biosciences and Bioengineering

2. Indian Institute of Technology Guwahati

3. Guwahati-781039

4. India

5. Department of Electronics and Electrical Engineering

Abstract

Potential use of electric field as a non-invasive therapeutic option against Alzheimer's disease, by modulating the aggregation kinetics and morphology of tau protein.

Funder

Board of Research in Nuclear Sciences

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference58 articles.

1. M.Prince , A.Comas-Herrera , M.Knapp , M.Guerchet and M.Karagiannidou , World Alzheimer Report 2016 Improving healthcare for people living with dementia. Coverage, Quality and costs now and in the future , 2016 , pp. 1–140 , https://www.alz.co.uk/research/world-report-2016

2. Green and Black Tea Polyphenols Mechanistically Inhibit the Aggregation of Amyloid-β in Alzheimer's Disease

3. Transient small molecule interactions kinetically modulate amyloid β peptide self-assembly

4. P1‐084: Small Molecule TAU Oligomerization Inhibitors

5. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

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