The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)-Reference-Cited by-同舟云学术

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The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide (AP39)

Published:2014 Issue:6 Volume:5 Page:728-736
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Le Trionnaire Sophie¹²³,Perry Alexis⁴⁵⁶⁷,Szczesny Bartosz⁸⁹¹⁰,Szabo Csaba⁸⁹¹⁰,Winyard Paul G.¹²³,Whatmore Jacqueline L.¹²³,Wood Mark E.⁴⁵⁶⁷,Whiteman Matthew¹²³

Affiliation:

1. University of Exeter Medical School

2. St. Luke's Campus

3. Exeter EX1 2LU, UK

4. Biosciences

5. College of Environmental and Life Sciences

6. University of Exeter

7. Exeter EX4 4QD, UK

8. Department of Anesthesiology

9. University of Texas Medical Branch

10. Galveston, USA

Abstract

Mitochondrial dysfunction is observed in many diseases. Targeting H₂S generation to mitochondria may be cytoprotective.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00323J

Reference55 articles.

1. Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

2. Hydrogen sulfide: a gasotransmitter of clinical relevance

3. 3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

4. Intramitochondrial hydrogen sulfide production by 3‐mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

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