Novel triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones as promising potential anticancer drug candidates: in vitro and in vivo evaluation

Author:

Kasalović Marijana P.12,Jelača Sanja3ORCID,Milanović Žiko4,Maksimović-Ivanić Danijela3,Mijatović Sanja3,Lađarević Jelena5,Božić Bojan6,Marković Zoran4ORCID,Dunđerović Duško7ORCID,Rüffer Tobias8ORCID,Kretschmer Robert8ORCID,Kaluđerović Goran N.1ORCID,Pantelić Nebojša Đ.19ORCID

Affiliation:

1. Department of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Straße 2, 06217 Merseburg, Germany

2. Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia

3. Department of Immunology, Institute for Biological Research “Siniša Stanković” National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia

4. Department of Science, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia

5. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia

6. Institute of Physiology and Biochemistry “Ivan Djaja”, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000 Belgrade, Serbia

7. Institute of Pathology, School of Medicine, University of Belgrade, dr Subotića 1, 11000, Belgrade, Serbia

8. Institute of Chemistry, Chemnitz University of Technology, Straße der Nationen 62, D-09111 Chemnitz, Germany

9. Department of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia

Abstract

Three triphenyltin(iv) compounds with carboxylato N-functionalized 2-quinolones are reported. The compounds showed remarkable anticancer activity in lower micromolar concentrations. The most active compound exhibited a better in vivo profile than cisplatin.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

German Academic Exchange Service

Publisher

Royal Society of Chemistry (RSC)

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