Design, synthesis and cytotoxicity of novel hexacyclic saframycin–ecteinascidin analogs
Author:
Affiliation:
1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines
2. Institute of Materia Medica
3. Peking Union Medical College and Chinese Academy of Medical Sciences
4. Beijing 100050
5. P. R. China
Abstract
Two series of novel tetrahydroisoquinoline–tetrahydrocarboline hybrid derivatives were prepared and their cytotoxicities were tested.
Funder
Chinese Academy of Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02426C
Reference21 articles.
1. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
2. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics
3. Increased production of saframycin A and isolation of saframycin S.
4. A new saframycin, saframycin R.
5. Saframycin S, a new saframycin group antibiotic.
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