Probing the substrate specificity ofTrypanosoma bruceiGlcNAc-PI de-N-acetylase with synthetic substrate analogues
Author:
Affiliation:
1. Division of Biological Chemistry and Drug Discovery
2. College of Life Sciences
3. University of Dundee
4. Dundee, UK
Abstract
A series of substrates analogues of GlcNAc-PI de-N-acetylase were tested as substrates and inhibitors of theTrypanosoma bruceienzyme.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42164C
Reference26 articles.
1. Differences between the trypanosomal and human GlcNAc-PI de-N-acetylases of glycosylphosphatidylinositol membrane anchor biosynthesis
2. Parasite-Specific Inhibition of the Glycosylphosphatidylinositol Biosynthetic Pathway by Stereoisomeric Substrate Analogues
3. Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors
4. ProbingTrypanosoma bruceiGlycosylphosphatidylinositol Biosynthesis Using Novel Precursor-Analogues
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