Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance-Reference-Cited by-同舟云学术

Retinal organoids on-a-chip: a micro-millifluidic bioreactor for long-term organoid maintenance

Published:2021 Issue:17 Volume:21 Page:3361-3377
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Xue Yuntian¹^ORCID,Seiler Magdalene J.²³⁴⁵^ORCID,Tang William C.¹^ORCID,Wang Jasmine Y.⁶,Delgado Jeffrey³,McLelland Bryce T.⁷,Nistor Gabriel⁷,Keirstead Hans S.⁷,Browne Andrew W.¹⁴⁸^ORCID

Affiliation:

1. Biomedical Engineering, University of California, Irvine, Irvine, CA, USA

2. Physical Medicine & Rehabilitation, University of California, Irvine, Irvine, CA, USA

3. Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA

4. Gavin Herbert Eye Institute Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA

5. Anatomy & Neurobiology, University of California, Irvine, Irvine, CA, USA

6. School of Biological Sciences, University of California, Irvine, Irvine, CA, USA

7. AIVITA Biomedical, Irvine, CA, USA

8. Institute for Clinical and Translational Science, University of California, Irvine, Irvine, CA, USA

Abstract

We described an automated microfluidic bioreactor manufactured using soft lithography from 3D printed molds, and optimized for long-term retinal organoid maintenance with functional imaging.

Funder

Research to Prevent Blindness

Institute of Clinical and Translational Sciences

California Institute for Regenerative Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00011J

Reference74 articles.

1. Vector platforms for gene therapy of inherited retinopathies