Next-Generation Molecular Markers: Challenges, Applications and Future Perspectives

Author:

Verma Mukesh1,Barh Debmalya2,Hassan Syed Shah3

Affiliation:

1. Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute (NCI), National Institutes of Health (NIH), 9609 Medical Center Drive   Rockville   MD 20850   USA

2. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB)   Nonakuri, Purba Medinipur   West Bengal-721172   India   dr.barh@gmail.com

3. Departamento de Biologia Geral, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais   Pampulha   Belo Horizonte   Minas Gerais   Brazil

Abstract

In this chapter we discuss the challenges in cancer biomarkers discovery. Furthermore, we discuss next-generation molecular markers and their applications in diagnostic screening, early diagnosis, risk assessment, prognosis and pharmacogenomics of immune diseases, cardiovascular diseases, metabolomic diseases, infectious diseases, neurological diseases and cancers. Additionally, we give brief accounts of therapeutic biomarkers for these selected diseases. Finally, we conclude the chapter with a future perspective on molecular biomarkers.

Publisher

The Royal Society of Chemistry

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