Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies-Reference-Cited by-同舟云学术

Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies

Published:2022 Issue:6 Volume:22 Page:1187-1205
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Docci Luca¹²,Milani Nicolò¹³^ORCID,Ramp Thomas¹^ORCID,Romeo Andrea A.¹^ORCID,Godoy Patricio¹,Franyuti Daniela Ortiz¹^ORCID,Krähenbühl Stephan²,Gertz Michael¹,Galetin Aleksandra³^ORCID,Parrott Neil¹,Fowler Stephen¹^ORCID

Affiliation:

1. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland

2. Clinical Pharmacology & Toxicology, University Hospital, Schanzenstrasse 55, 4031, Basel, Switzerland

3. Centre for Applied Pharmacokinetic Research, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK

Abstract

Microphysiological systems (MPS) are complex and more physiologically realistic cellular in vitro tools that aim to provide more relevant human in vitro data for quantitative prediction of clinical pharmacokinetics while also reducing the need for animal testing.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D1LC01161H

Reference63 articles.

1. A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes

2. Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

3. Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-β-Glucuronide

4. Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro–In Vivo Scaling of Hepatic Uptake Clearance

5. Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

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