How do mutations affect the structural characteristics and substrate binding of CYP21A2? An investigation by molecular dynamics simulations
Author:
Affiliation:
1. Laboratory of Theoretical and Computational Chemistry
2. Institute of Theoretical Chemistry
3. International Joint Research Laboratory of Nano-Micro Architecture Chemistry
4. Jilin University
5. Changchun 130023
Abstract
CYP21A2 mutations affect the activity of the protein leading to CAH disease.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2020/CP/D0CP00763C
Reference51 articles.
1. Steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia
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4. Generation of monoclonal antibodies against 17α-hydroxyprogesterone for newborn screening of congenital adrenal hyperplasia
5. Genetics of Congenital Adrenal Hyperplasia
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