Modeling the <i>syn</i>-cycle in the light activated opening of the channelrhodopsin-2 ion channel-Reference-Cited by-同舟云学术

Modeling the syn-cycle in the light activated opening of the channelrhodopsin-2 ion channel

Published:2022 Issue:11 Volume:12 Page:6515-6524
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xin Qi¹,Cheng Jie¹,Wang Hongwei²,Zhang Wenying¹,Lu Hong¹,Zhou Junpeng¹,Lo Glenn V.³,Dou Yusheng³,Yuan Shuai¹^ORCID

Affiliation:

1. Chongqing Key Laboratory of Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 40065, China

2. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane St Lucia, QLD 4072, Australia

3. Department of Chemistry and Physical Sciences, Nicholls State University, P.O. Box 2022, Thibodaux, LA 70310, USA

Abstract

Modelling the syn-cycle is a series of operations on the ChR2 crystal structure (PDB ID: 6EID). By replacement and isomerization, we obtained P500* and P480 intermediates. A feasible explanation that no P390* was observed in experiment was inferred.

Funder

Natural Science Foundation of Chongqing

Chongqing Municipal Education Commission Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08521B

Reference55 articles.

1. Controlling neural circuits with light

2. Multimodal fast optical interrogation of neural circuitry

3. In Vivo Mapping of Cortical Columnar Networks in the Monkey with Focal Electrical and Optical Stimulation

4. Automated, highly reproducible, wide-field, light-based cortical mapping method using a commercial stereo microscope and its applications

5. Biophysical Properties of Optogenetic Tools and Their Application for Vision Restoration Approaches