Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility-Reference-Cited by-同舟云学术

Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility

Published:2015 Issue:4 Volume:4 Page:843-847
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Elgawish Mohamed Saleh¹²³⁴⁵,Kishikawa Naoya¹²³⁴⁵,Helal Mohamed A.⁶⁷⁸⁹¹⁰,Ohyama Kaname¹²³⁴⁵,Kuroda Naotaka¹²³⁴⁵

Affiliation:

1. Graduate School of Biomedical Sciences

2. Course of Pharmaceutical Sciences

3. Nagasaki University

4. Nagasaki 852-8521

5. Japan

6. Medicinal Chemistry Department

7. Faculty of Pharmacy

8. Suez Canal University

9. Ismailia 41522

10. Egypt

Abstract

The toxicity, reversibility and selectivity of quinone–protein adducts were studied using molecular modeling and molecular spectroscopy. Adduction of quinones with proteins could affect their redox potential, bioavailability, and intracellular distribution.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TX/C5TX00098J

Reference24 articles.

1. The Chemical Biology of Naphthoquinones and Its Environmental Implications

2. QUINOENZYMES IN BIOLOGY

3. Role of Quinones in Toxicology

4. The Metabolism and Toxicity of Quinones, Quinonimines, Quinone Methides, and Quinone-Thioethers

5. Development and Validation of the First Assay Method Coupling Liquid Chromatography with Chemiluminescence for the Simultaneous Determination of Menadione and Its Thioether Conjugates in Rat Plasma

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