Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk-Reference-Cited by-同舟云学术

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

Published:2023 Issue:10 Volume:4 Page:765-773
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Zhou Wenyuan¹,Ryan Amy¹,Janosko Chasity P.¹,Shoger Karsen E.²³,Haugh Jason M.⁴,Gottschalk Rachel A.²³,Deiters Alexander¹³^ORCID

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA

2. Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA

3. Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA

4. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27606, USA

Abstract

Protein isoforms are difficult to differentiate in a cellular context. Here, we describe the acute light control of individual isoforms of the mitogen-activated protein kinase (MAPK) p38, revealing a novel point of crosstalk between two MAPK pathways.

Funder

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CB/D2CB00157H

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