A novel active mitochondrion-selective fluorescent probe for the NIR fluorescence imaging and targeted photodynamic therapy of gastric cancer-Reference-Cited by-同舟云学术

A novel active mitochondrion-selective fluorescent probe for the NIR fluorescence imaging and targeted photodynamic therapy of gastric cancer

Published:2022 Issue:17 Volume:10 Page:4756-4763
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Ding Jie¹²,Kang Xing²,Feng Min²,Tan Jiangkun³,Feng Qingzhao²,Wang Xingzhou²,Wang Jiafeng²⁴,Liu Jiang⁵,Li Zan³^ORCID,Guan Wenxian²,Qiao Tong¹

Affiliation:

1. Department of Vascular Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, 210008, China

2. Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China

3. Key Laboratory of Life-Organic Analysis of Shandong Province, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, 273165, China

4. Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China

5. Department of General Surgery, Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210004, China

Abstract

Cy1395-NPs selectively accumulate in gastric cancer cells through attachment mediated by integrin αvβ3 and target the mitochondria, achieving NIR fluorescence imaging and PDT via the generation of 1O2 under laser irradiation.

Funder

National Natural Science Foundation of China

Six Talent Peaks Project in Jiangsu Province

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00684G

Reference79 articles.

1. The ever‐increasing importance of cancer as a leading cause of premature death worldwide