Mechanistic insight into the selective crystallization of the metastable polymorph of tolbutamide in ethanol

Mechanistic insight into the selective crystallization of the metastable polymorph of tolbutamide in ethanol–water solution

Published:2014 Issue:41 Volume:4 Page:21599-21607
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Zhang Jinli¹²³,Wu Yujia¹²³,Liu Anyuan¹²³,Li Wei¹²³,Han You¹²³

Affiliation:

1. School of Chemical Engineering & Technology

2. Tianjin University

3. Tianjin 300072, People's Republic of China

Abstract

A combined experimental and molecular dynamics simulation study discloses the effects of solvents and supersaturation on the tolbutamide polymorphs outcome.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA01705F

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