Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways-Reference-Cited by-同舟云学术

Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways

Published:2024 Issue:18 Volume:14 Page:12864-12872
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhong Lili¹,Fu Datian²,Xu Jin³,Tan Linyan⁴,Wu Haimei⁵^ORCID,Wang Min¹

Affiliation:

1. Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, Hainan, 570311, China

2. Department of Pharmacy, Hainan Women and Children's Medical Center, Haikou, Hainan, 570312, China

3. Pharmaceutical and Bioengineering School, Hunan Chemical Vocational Technology College, Zhuzhou, 412006, China

4. Department of Pharmacy, Tropical Agricultural Technology College, Hainan Vocational University, Haikou, Hainan, 570216, China

5. Department of Clinical Pharmacy, Hainan Cancer Hospital, Haikou, Hainan, 570100, China

Abstract

A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00562G

Reference56 articles.

1. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

2. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

3. Ferroptosis: mechanisms, biology and role in disease

4. The Relationship Between Ferroptosis and Diseases

5. Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases