Fluorination methods in drug discovery-Reference-Cited by-同舟云学术

Fluorination methods in drug discovery

Published:2016 Issue:36 Volume:14 Page:8398-8427
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yerien Damian E.¹²³⁴⁵,Bonesi Sergio¹⁶⁷⁸⁹,Postigo Al¹²³⁴⁵

Affiliation:

1. Departamento de Química Orgánica

2. Facultad de Farmacia y Bioquímica

3. Universidad de Buenos Aires-CONICET

4. 1113-Buenos Aires

5. Argentina

6. CIHIDECAR-CONICET

7. Pabellón II

8. 3er piso

9. Ciudad Universitaria

Abstract

Late stage fluorination methods applied to biologically-active drugs have provided the pharmaceutical industry with new leads that show improved properties such as modulation of lipophilicity, electronegativity, basicity, bioavailability, and deceleration of metabolic degradation.

Funder

Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00764C

Reference212 articles.

1. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

2. Organofluorine chemistry: applications, sources and sustainability

3. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)