Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects
Author:
Affiliation:
1. College of Bioinformatics Science and Technology
2. Harbin Medical University
3. Harbin
4. P. R. China
Abstract
Drug side effects, or adverse drug reactions (ADRs), have become a major public health concern and often cause drug development failure and withdrawal.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00242G
Reference39 articles.
1. When good drugs go bad
2. Relating drug-protein interaction network with drug side effects
3. Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors
4. Chemical biology and the limits of reductionism
5. Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?
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