Light-stable polypyridine silver(i) complexes of 1,3,5-triaza-7-phosphaadamantane (PTA) and 1,3,5-triaza-7-phosphaadamantane-7-sulfide (PTAS): significant antiproliferative activity of representative examples in aqueous media

Author:

Jaros Sabina W.1234ORCID,Śliwińska-Hill Urszula56784,Białońska Agata56784,Nesterov Dmytro S.910111213ORCID,Kuropka Piotr1415164,Sokolnicki Jerzy1234,Bażanów Barbara1718164,Smoleński Piotr1234ORCID

Affiliation:

1. Faculty of Chemistry

2. University of Wroclaw

3. 50-383 Wrocław

4. Poland

5. Department of Analytical Chemistry

6. Faculty of Pharmacy

7. Wroclaw Medical University

8. 50-566 Wrocław

9. Centro de Química Estrutural

10. Instituto Superior Técnico

11. Universidade de Lisboa

12. 1049-001 Lisboa

13. Portugal

14. Department of Histology and Embryology

15. Wroclaw University of Environmental and Life Sciences

16. 50-375 Wrocław

17. Department of Veterinary Microbiology

18. Wrocław University of Environmental and Life Sciences

Abstract

A series of novel silver polypyridine complexes containing PTA or PTAS have been synthesized and fully characterized. Representative light-stable and water-soluble complexes were evaluated for their cytotoxic and the antitumor activity.

Funder

Narodowe Centrum Nauki

Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa

Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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