Quantification and molecular imaging of fatty acid isomers from complex biological samples by mass spectrometry

Author:

Zhang Hua1234ORCID,Xu Meng5234ORCID,Shi Xudong67823,Liu Yuan1234ORCID,Li Zihui5234ORCID,Jagodinsky Justin C.98234,Ma Min1234,Welham Nathan V.67823ORCID,Morris Zachary S.98234,Li Lingjun12345ORCID

Affiliation:

1. School of Pharmacy

2. University of Wisconsin–Madison

3. Madison

4. USA

5. Department of Chemistry

6. Division of Otolaryngology

7. Department of Surgery

8. School of Medicine and Public Health

9. Department of Human Oncology

Abstract

A structural lipidomics approach employs peracetic acid-induced epoxidation coupled with mass spectrometry for pinpointing CC bonds in unsaturated fatty acids, enabling both quantification and imaging of FA isomers from biological samples.

Funder

National Institute on Aging

NIH Office of the Director

National Institute of Mental Health

National Center for Research Resources

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Wisconsin Alumni Research Foundation

University of Wisconsin–Madison

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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