Optical control of the nuclear bile acid receptor FXR with a photohormone-Reference-Cited by-同舟云学术

Optical control of the nuclear bile acid receptor FXR with a photohormone

Published:2020 Issue:2 Volume:11 Page:429-434
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Morstein Johannes¹²³⁴^ORCID,Trads Julie B.¹⁵⁶⁷⁸,Hinnah Konstantin¹²³⁴,Willems Sabine⁹¹⁰¹¹⁸,Barber David M.¹⁵⁶⁷⁸,Trauner Michael¹²¹³¹⁴¹⁵¹⁶,Merk Daniel⁹¹⁰¹¹⁸^ORCID,Trauner Dirk¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. New York University

3. New York

4. USA

5. Center for Integrated Protein Science

6. Ludwig Maximilians University Munich

7. 81377 Munich

8. Germany

9. Institute of Pharmaceutical Chemistry

10. Goethe-University Frankfurt

11. 60438 Frankfurt

12. Hans Popper Laboratory of Molecular Hepatology

13. Division of Gastroenterology and Hepatology

14. Department of Internal Medicine III

15. Medical University of Vienna

16. 1090 Vienna

Abstract

Herein, we report a photoswitchable modulator for a nuclear hormone receptor that exerts its hormonal effects in a light-dependent fashion.

Funder

New York University

European Commission

Danmarks Grundforskningsfond

Aarhus Universitet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC02911G

Reference22 articles.

1. Nuclear Receptors, RXR, and the Big Bang

2. Principles for modulation of the nuclear receptor superfamily

3. A comprehensive map of molecular drug targets

4. Overview of Nomenclature of Nuclear Receptors|Pharmacological Reviews, http://pharmrev.aspetjournals.org/content/58/4/685.long , accessed Dec 10, 2018

5. FXR, a multipurpose nuclear receptor

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