Concise total synthesis of (±)-aspidospermidine-Reference-Cited by-同舟云学术

Concise total synthesis of (±)-aspidospermidine

Published:2015 Issue:18 Volume:13 Page:5255-5259
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ma Haichen¹²³⁴⁵,Xie Xingang¹²³⁴⁵,Jing Peng¹²³⁴⁵,Zhang Weiwei¹²³⁴⁵,She Xuegong¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry

2. College of Chemistry and Chemical Engineering

3. Lanzhou University

4. Lanzhou

5. People's Republic of China

Abstract

(±)-Aspidospermidine (1) has been synthesized from the commercially available 2,3-dihydro-1H-carbazol-4(9H)-one 6 in 10 steps with 20% overall yield. The key step of the strategy is a one-pot carbonyl reduction/iminium formation/intramolecular conjugate addition reaction that may be applied for the synthesis of other kinds of Aspidosperma alkaloids.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00228A

Reference32 articles.

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