Transferrin-inspired iron delivery across the cell membrane using [(L<sub>2</sub>Fe)<sub>2</sub>(μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis-Reference-Cited by-同舟云学术

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Transferrin-inspired iron delivery across the cell membrane using [(L₂Fe)₂(μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis

Published:2024 Issue:7 Volume:53 Page:3206-3214
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Abeydeera Nalin¹,Mudarmah Khalil¹²,Pant Bishnu D.¹,Krause Jeanette A.³,Zheng Yao-Rong¹^ORCID,Huang Songping D.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA

2. On leave from Department of Chemistry, Jazan University, Jazan, 45142, Saudi Arabia

3. Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA

Abstract

Don't waste good iron for nails (or good men for soldiers) but save it for treating cancer! The lipophilic Fe(iii) chelator chlorquinaldol has the remarkable ability to transport iron across the cell membrane afford potent broad-spectrum in vitro anticancer activity against a panel of cancer cell lines.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT02517A

Reference30 articles.

1. Mechanisms of Mammalian Iron Homeostasis

2. Mechanisms of Cellular Iron Acquisition

3. The role of iron and reactive oxygen species in cell death

4. Toxicity of iron and hydrogen peroxide: the Fenton reaction

5. The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

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