Glycal approach to the synthesis of macrolide (−)-A26771B

Author:

Saidhareddy Puli1234,Shaw Arun K.1234

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR-Central Drug Research Institute (CDRI)

3. Lucknow-226031

4. India

Abstract

A convergent synthesis of macrolide natural product (−)-A26771B starting from d-glucal is reported. Key features of this synthesis involve Ferrier rearrangement, cross metathesis of chiral fragments 3 and 4 and Yamaguchi macrolactonization.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference42 articles.

1. For recent reviews, see: S.Omura, Macrolide Antibiotics. Chemistry, Biology, and Practice, 2nd edn, Academic Press Inc., 2002

2. The evolution and role of macrolides in infectious diseases

3. The macrolides

4. Macrolide myths

5. Throwing a spanner in the works: antibiotics and the translation apparatus

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